I think it is likely that this number refers at least to Nero. If this is the case it has implications for the dating of the book of Revelation which I think was written prior to 70 AD.
In this passage we note the the number of the beast is the number of a man. This does not necessarily mean that the beast is a man, just that the number of the beast is the number of a man.
The number of a man may be the number of the name via gematria. Nero Caesar's number in Greek is 1337, but his number in Hebrew is 666. The call for wisdom may have meant that the number needed to be calculated in Hebrew, not Greek. The association with Nero is very ancient, almost certainly as old as the book of Revelation. Nero Caesar does not have a gematria in Latin (that I am aware of), the Latin numbering scheme does not lend itself to this. But transliteration of Nero Caesar from Latin to Hebrew gives the number 616 which is mentioned in several manuscripts of Revelation. This confirms that the authors of the variant manuscripts thought Nero was intended. Below are the calculations.
Though Nero's gematria in Greek is given by Suetonius without the Caesar resulting in 1005.